Characterization of a new use for acyclovir and tenofovir using human cervico- vaginal tissue ex vivo
نویسندگان
چکیده
Background: HSV-2, one of the most common HIV-1 copathogens, establishes a synergistic interaction with HIV-1. Several clinical trials have shown that the anti herpetic drug acyclovir decreases HIV-1 viral load and delays HIV-1 disease progression. Similarly, CAPRISA004 reported that a vaginal gel containing 1% of the anti-HIV-1 drug tenofovir unexpectedly decreases the risk of HSV-2 acquisition by 51%. Using a system of cervicovaginal tissue culture that reflects many of the in vivo tissue features, we evaluated the dual anti-HIV-1/HSV-2 activity of acyclovir and tenofovir.
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